Van de Ven Brace Ends The Toffees' Run at Brand New Stadium
Micky van de Ven emerged as the initial defender to net two goals in a English top-flight game for Spurs since Jan Vertonghen in March 2013.
Match summary
The Spurs defender nods home two times in opening period
Everton's defender has goal disallowed after video check
Pape Matar Sarr scores final goal in dying moments
This loss is Everton's initial at Hill Dickinson Stadium
Micky van de Ven scored on two occasions as Spurs prolonged their unbeaten run on the road in the top division and delivered the Toffees their first defeat at Hill Dickinson Stadium.
Everton were undefeated in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the end of the previous campaign.
But Tottenham's leader the Dutchman pounced twice from set-pieces in the first half to put their impressive record at risk, and they were unable to mount a comeback before the midfielder - assisted by former Toffees attacker the Brazilian - nodded in a third to seal the victory.
The Everton defender believed he had equalized the tally five minutes after Van de Ven's opener, directing a bullet header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, meanwhile, failed to convert a number of opportunities, while Vicario made a series of excellent stops to ensure the London club went five away games unbeaten in the Premier League.
But the VAR stepped in, instructing the match official to check the goal on the pitchside monitor and the official decided that the winger and the attacker were in an illegal position and had interfered with the Tottenham goalkeeper.
This victory moves the manager's team up to third in the division, five points off local foes and leaders Arsenal.
The Merseyside club remain 14th and are six points ahead of the drop zone.
Spurs breakdown: The defender excels in duties at each end of pitch
After a drab weekday display in the European competition against Monaco, where they mustered a mere attempts on goal, Frank chose the French striker up front instead of ex-Everton forward the Brazilian.
The new arrival was failed to make much of an impact before being replaced for Richarlison after an hour on the pitch, but it emerged he wasn't needed in the final outcome.
Centre-back the Dutchman transformed into an attacking force to be feared.
Tottenham's first goal came from a cleverly executed corner routine, with the midfielder directing the ball back across the six-yard box for an unmarked Van de Ven to head home.
And the captain - filling in as skipper in Cristian Romero's unavailability - notched his second in added time as he rose above the England keeper to head home.
The Dutchman was just as outstanding in defensive duties, combining effectively with Kevin Danso as the duo handled superbly with the 34 crosses sent their way by Everton.
Everton analysis: Everton lacking striker's instinct
The club's recent stadium had been a fortress, but it appears the freshness may have faded somewhat and supporters flocked to the gates after Sarr's third for Tottenham.
The break in Everton's unbeaten home run won't be a massive concern for David Moyes, but their striker situation will be.
The forward and the other striker - the Toffees' two established centre-forwards - had scored only one league goal between them before Sunday's match.
And they were unable to contribute to that poor tally on a damp and dreary night on in Liverpool.
The striker's form was summed up when he opted to overhead kick a golden opportunity from near the goal, despite having room and opportunity to readjust for a more conventional attempt that would have challenged the keeper.
Barry, as well, was unable to make an impact after coming on for Beto in the 65th minute.
It was not for a lack of opportunity. The majority of the home side's attacks came through Grealish and Ndiaye, who relentlessly delivered dangerous crosses into the Tottenham box.
Upcoming fixtures for these two sides?
The Toffees: The team travel to the Stadium of Light in the Premier League on early November at 20:00 GMT.
Tottenham: The London club travel to St James' Park on late October for their next round Carabao Cup tie against Newcastle.